DHCR7 Polyclonal Antibody | G-AB-12012
- 3 to 5 Working Days
DHCR7 Polyclonal Antibody | G-AB-12012 | Gentaur Antibodies
Overview: This gene encodes an enzyme that removes the C (7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS) ; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction
Synonyms: DHCR7, SLOS
Gene ID: 1717
Immunogen: Recombinant fusion protein of human DHCR7 (NP_001351.2) .
Calculated MW: 54 kDa
Observed MW: 70 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.