DMTN Polyclonal Antibody | G-AB-03649

DMTN Polyclonal Antibody | G-AB-03649 | Gentaur Antibodies

Overview: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. DMTN (Dematin Actin Binding Protein) is a Protein Coding gene. Diseases associated with DMTN include Hypotrichosis and Hereditary Spherocytosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. GO annotations related to this gene include receptor binding and protein self-association. An important paralog of this gene is ABLIM1.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: DEMA, DEMA, Dematin, DMT, EPB49, erythrocyte membrane protein band 4.9 (dematin) , Erythrocyte membrane protein band 4.9

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP001107607

Clonality: Polyclonal

Immunogen: Synthetic peptide of human DMTN

Clone #:

Conjugation: Unconjugated

Swissprot: Q08495

Santa Cruz:

Calculated MW: 46 kDa

Observed MW: Refer to figures

Concentration: 1.5 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:20-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DMTN Polyclonal Antibody DataSheet