ERBB2 Monoclonal Antibody | G-AB-05516

ERBB2 Monoclonal Antibody | G-AB-05516 | Gentaur Antibodies

Overview: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs) . Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Immunology, Signal Transduction, Tags & Cell Markers

Synonyms: Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, C erb B2/neu protein, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, Erb b2 receptor tyrosine kinase 2, ERBB2, ERBB2, HER 2, HER 2/NEU, HER2, Herstatin, Human epidermal growth factor receptor 2, Metastatic lymph node gene 19 protein, MLN 19, MLN19, NEU, NEU proto oncogene, Neuro/glioblastoma derived oncogene homolog, Neuroblastoma/glioblastoma derived oncogene homolog, NGL, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase type cell surface receptor HER2, Tyrosine kinase-type cell surface receptor HER2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) , V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) , V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide

Clone #: Clone:1J5

Conjugation: Unconjugated

Swissprot: P04626

Santa Cruz:

Calculated MW: 138 kDa

Observed MW: 138 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification method: Protein A purification

Application: WB, IHC-p, IF

Dilution: WB 1:500-1:4000, IHC 1:100-1:300, IF 1:100-1:300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERBB2 Monoclonal Antibody DataSheet