ERCC6L Polyclonal Antibody | G-AB-00974

ERCC6L Polyclonal Antibody | G-AB-00974 | Gentaur Antibodies

Overview: PICH (Plk1-interacting checkpoint helicase) , also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1, 250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: ATP dependent helicase ERCC6 like, ATP-dependent helicase ERCC6-like, DNA excision repair protein ERCC 6 like, DNA excision repair protein ERCC-6-like, ERC6L, ERCC 6L, Ercc6l, Excision repair cross complementing rodent repair deficiency complementation group 6 like, Excision repair protein ERCC6 like, FLJ20105, MGC131695, PICH, Plk1 interacting checkpoint helicase, PLK1-interacting checkpoint helicase, SNF2/RAD54 family protein, Tumor antigen BJ HCC 15, Tumor antigen BJ-HCC-15

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC008808

Clonality: Polyclonal

Immunogen: Recombinant protein of human ERCC6L

Clone #:

Conjugation: Unconjugated

Swissprot: Q2NKX8

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERCC6L Polyclonal Antibody DataSheet