ERH Polyclonal Antibody | G-AB-06741

ERH Polyclonal Antibody | G-AB-06741 | Gentaur Antibodies

Overview: ERH (enhancer of rudimentary homolog) , also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1) . HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: DROER, Enhancer of rudimentary homolog (Drosophila) , Enhancer of rudimentary homolog, ERH, ERH, FLJ27340, HGNC:3447

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC014301

Clonality: Polyclonal

Immunogen: Fusion protein of human ERH

Clone #:

Conjugation: Unconjugated

Swissprot: P84090

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERH Polyclonal Antibody DataSheet