ERN2 Polyclonal Antibody | G-AB-03141

ERN2 Polyclonal Antibody | G-AB-03141 | Gentaur Antibodies

Overview: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein) . IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: IRE1b, IRE1-BETA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_150296

Clonality: Polyclonal

Immunogen: Synthetic peptide of human ERN2

Clone #:

Conjugation: Unconjugated

Swissprot: Q76MJ5

Santa Cruz: sc-20575/sc-10512/sc-20576/sc-25563

Calculated MW:

Observed MW:

Concentration: 1.1 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERN2 Polyclonal Antibody DataSheet