EWSR1 Polyclonal Antibody | G-AB-08519

EWSR1 Polyclonal Antibody | G-AB-08519 | Gentaur Antibodies

Overview: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Tags & Cell Markers

Synonyms: EWSR1, EWS, EWS-FLI1, bK984G1.4

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 2130

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human EWSR1 (NP_001156757.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q01844

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

EWSR1 Polyclonal Antibody DataSheet