FANCD2 Polyclonal Antibody | G-AB-09920

FANCD2 Polyclonal Antibody | G-AB-09920 | Gentaur Antibodies

Overview: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2) , FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1) , FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: FA4, FAD, FACD, FAD2, FA-D2, FANCD, FANCD2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 2177

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human FANCD2 (NP_149075.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9BXW9

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FANCD2 Polyclonal Antibody DataSheet