FEN1 Polyclonal Antibody | G-AB-07620

FEN1 Polyclonal Antibody | G-AB-07620 | Gentaur Antibodies

Overview: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: FEN1, FEN-1, MF1, RAD2

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 2237

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human FEN1 (NP_004102.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P39748

Santa Cruz:

Calculated MW: 35 kDa/42 kDa

Observed MW: 48 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FEN1 Polyclonal Antibody DataSheet