FGFR1 Polyclonal Antibody | G-AB-09921
Gentaur Antibodies
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Gentaur Antibodies
FGFR1 Polyclonal Antibody | G-AB-09921
- SKU:
- G-AB-09921
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Mouse
FGFR1 Polyclonal Antibody | G-AB-09921 | Gentaur Antibodies
Overview: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction
Synonyms: FGFR1, BFGFR, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1
Reactivity: Mouse
Host: Rabbit
Isotype: IgG
Gene ID: 2260
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human FGFR1 (NP_075598.2) .
Clone #:
Conjugation: Unconjugated
Swissprot: P11362
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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