FOXO1 Polyclonal Antibody | G-AB-05293

FOXO1 Polyclonal Antibody | G-AB-05293 | Gentaur Antibodies

Overview: FOXO1, also named as FOXO1A, FKHR and FKH1, is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1, FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24, Ser-256, and Ser-319) that are conserved in other FOXO proteins. The t (2;13) and the variant t (1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal Transduction

Synonyms: FKH 1, FKH1, FKHR, Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) , Forkhead box O1, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma, FoxO transcription factor, foxo1, FOXO1, FOXO1A, OTTHUMP00000018301

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant protein corresponding to Mouse FOXO1

Clone #:

Conjugation: Unconjugated

Swissprot: Q9R1E0, G3V7R4

Santa Cruz:

Calculated MW: 78-82 kDa

Observed MW: 78 kDa

Concentration: 0.58 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FOXO1 Polyclonal Antibody DataSheet