FXYD1 Polyclonal Antibody | G-AB-08927

FXYD1 Polyclonal Antibody | G-AB-08927 | Gentaur Antibodies

Overview: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel) . FXYD2, also known as the gamma subunit of the Na, K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman) , FXYD2 (gamma) , FXYD3 (MAT-8) , FXYD4 (CHIF) , and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2) , with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms: FXYD1, PLM

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5348

Accession #:

Clonality:

Immunogen: A synthetic peptide of human FXYD1 (NP_005022.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: O00168

Santa Cruz:

Calculated MW: 10 kDa

Observed MW: 16 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FXYD1 Polyclonal Antibody DataSheet