GNB3 Polyclonal Antibody | G-AB-08461

GNB3 Polyclonal Antibody | G-AB-08461 | Gentaur Antibodies

Overview: Heterotrimeric guanine nucleotide-binding proteins (G proteins) , which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain Signal Transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms: GNB3, CSNB1H

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 2784

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human GNB3 (NP_002066.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P16520

Santa Cruz:

Calculated MW: 32 kDa/37 kDa

Observed MW: 37 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GNB3 Polyclonal Antibody DataSheet