GRM3 Polyclonal Antibody | G-AB-00531

GRM3 Polyclonal Antibody | G-AB-00531 | Gentaur Antibodies

Overview: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative Signal Transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Signal Transduction

Synonyms: GLUR3, Glutamate metabotropic receptor 3, Glutamate receptor metabotropic 3, GPRC1C, GRM3, GRM3, Metabotropic glutamate receptor 3, MGlu3, mGluR3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC041407

Clonality: Polyclonal

Immunogen: Recombinant protein of human GRM3

Clone #:

Conjugation: Unconjugated

Swissprot: Q14832

Santa Cruz: sc-47139/sc-47138/sc-47137/sc-99042

Calculated MW:

Observed MW:

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GRM3 Polyclonal Antibody DataSheet