GRM8 Polyclonal Antibody | G-AB-10229

GRM8 Polyclonal Antibody | G-AB-10229 | Gentaur Antibodies

Overview: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative Signal Transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience

Synonyms: GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 2918

Accession #:

Clonality:

Immunogen: A synthetic peptide of human GRM8

Clone #:

Conjugation: Unconjugated

Swissprot: O00222

Santa Cruz:

Calculated MW: 55 kDa/101 kDa

Observed MW: 120 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GRM8 Polyclonal Antibody DataSheet