GSK3 beta Monoclonal Antibody | G-AB-05692

GSK3 beta Monoclonal Antibody | G-AB-05692 | Gentaur Antibodies

Overview: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Stem Cells

Synonyms: Glycogen Synthase Kinase 3 Beta, Glycogen synthase kinase-3 beta, GSK 3 beta, GSK-3 beta, GSK3B, GSK3B, GSK3beta isoform, Serine/threonine-protein kinase GSK3B

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide of GSK3β

Clone #: Clone:2C6

Conjugation: Unconjugated

Swissprot: P49841

Santa Cruz:

Calculated MW:

Observed MW: 46 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Protein A purification

Application: WB, IHC-p

Dilution: WB 1:1000-2000, IHC 1:100-200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GSK3 beta Monoclonal Antibody DataSheet