GSK3 beta Polyclonal Antibody | G-AB-05894
Gentaur Antibodies
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Gentaur Antibodies
GSK3 beta Polyclonal Antibody | G-AB-05894
- SKU:
- G-AB-05894
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
GSK3 beta Polyclonal Antibody | G-AB-05894 | Gentaur Antibodies
Overview: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Stem Cells
Synonyms: Glycogen Synthase Kinase 3 Beta, Glycogen synthase kinase-3 beta, GSK 3 beta, GSK-3 beta, GSK3B, GSK3B, GSK3beta isoform, Serine/threonine-protein kinase GSK3B
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: Synthesized peptide derived from human GSK3β around the non-phosphorylation site of Ser9.
Clone #:
Conjugation: Unconjugated
Swissprot: P49841
Santa Cruz: sc-8257/sc-9166
Calculated MW: 47 kDa
Observed MW: 47 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification method: Affinity purification
Application: WB, IHC-p, IF, ELISA
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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