GSTA2 Polyclonal Antibody | G-AB-11803

GSTA2 Polyclonal Antibody | G-AB-11803 | Gentaur Antibodies

Overview: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Category Type: Polyclonal Antibody

Research Areas: Metabolism, Signal Transduction

Synonyms: GSTA2, GST2, GSTA2-2, GTA2, GTH2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 2939

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human GSTA2 (NP_000837.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: P09210

Santa Cruz:

Calculated MW: 25 kDa

Observed MW: 25 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GSTA2 Polyclonal Antibody DataSheet