HLA-DMB Polyclonal Antibody | G-AB-12169

HLA-DMB Polyclonal Antibody | G-AB-12169 | Gentaur Antibodies

Overview: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 3109

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HLA-DMB (NP_002109.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P28068

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DMB Polyclonal Antibody DataSheet