HLA-DQA1 Polyclonal Antibody | G-AB-09988

HLA-DQA1 Polyclonal Antibody | G-AB-09988 | Gentaur Antibodies

Overview: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB) , both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: HLA-DQA1, CELIAC1, DQ-A1, HLA-DQA, CD, GSE, class II

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 3117

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HLA-DQA1 (NP_002113.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P01909

Santa Cruz:

Calculated MW: 27 kDa

Observed MW: 28 kDa-37KD

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DQA1 Polyclonal Antibody DataSheet