HLA-DRB3 Polyclonal Antibody | G-AB-09317

HLA-DRB3 Polyclonal Antibody | G-AB-09317 | Gentaur Antibodies

Overview: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: HLA-DRB3, HLA-DR1B, HLA-DR3B, major histocompatibility complex, class II, DR beta 3

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 3125

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HLA-DRB3 (NP_072049.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P79483

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DRB3 Polyclonal Antibody DataSheet