HMGCS1 Polyclonal Antibody | G-AB-01714

HMGCS1 Polyclonal Antibody | G-AB-01714 | Gentaur Antibodies

Overview: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms: 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) , 3-hydroxy-3-methylglutaryl coenzyme A synthase, cytoplasmic, EC 2.3.3.10, HMCS1, HMG CoA synthase, HMG-CoA synthase, HMGCS, HMGCS1, Hydroxymethylglutaryl CoA synthase, cytoplasmic, Hydroxymethylglutaryl-CoA synthase, MGC90332

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_001091742

Clonality: Polyclonal

Immunogen: Synthetic peptide of human HMGCS1

Clone #:

Conjugation: Unconjugated

Swissprot: Q01581

Santa Cruz: sc-32422/sc-32423/sc-33829

Calculated MW: 57 kDa

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HMGCS1 Polyclonal Antibody DataSheet