HUS1 Polyclonal Antibody | G-AB-06468

HUS1 Polyclonal Antibody | G-AB-06468 | Gentaur Antibodies

Overview: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC) , which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: Checkpoint protein HUS1, hHUS1, HUS1 (S. pombe) checkpoint homolog, Hus1, HUS1 checkpoint homolog (S. pombe) , HUS1 Checkpoint Protein, HUS1 protein, HUS1+ - like protein, HUS1, Hydroxyurea-sensitive 1, S. pombe, homolog of

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC007013

Clonality: Polyclonal

Immunogen: Fusion protein of human HUS1

Clone #:

Conjugation: Unconjugated

Swissprot: O60921

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.78 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HUS1 Polyclonal Antibody DataSheet