IL10 Polyclonal Antibody | G-AB-05378

IL10 Polyclonal Antibody | G-AB-05378 | Gentaur Antibodies

Overview: Interleukin (IL) -10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to IL-10

Clone #:

Conjugation: Unconjugated

Swissprot: P18893, P29456

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 150 μg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:200-1:1000, IF 1:200-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IL10 Polyclonal Antibody DataSheet