IL12B Polyclonal Antibody | G-AB-04913

IL12B Polyclonal Antibody | G-AB-04913 | Gentaur Antibodies

Overview: Interleukin-12 (IL-12) , is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs) , including phagocytes, B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS) , suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL 12B, IL-12 subunit p40, IL-12B, IL12 p40, IL12B, IL12B, IMD28, IMD29, Interleukin 12 beta chain, Interleukin 12 p40, Interleukin-12 subunit beta, NK cell stimulatory factor chain 2, NKSF, NKSF2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP002178

Clonality: Polyclonal

Immunogen: Synthetic peptide of human IL12B

Clone #:

Conjugation: Unconjugated

Swissprot: P29460

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.32 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IL12B Polyclonal Antibody DataSheet