IMPA1 Polyclonal Antibody | G-AB-06348

IMPA1 Polyclonal Antibody | G-AB-06348 | Gentaur Antibodies

Overview: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular Signal Transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms: IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1, IMPase 1, IMPase, Inositol 1 (or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol (myo) 1 (or 4) monophosphatase 1, Inositol-1 (or 4) -monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC009565

Clonality: Polyclonal

Immunogen: Fusion protein of human IMPA1

Clone #:

Conjugation: Unconjugated

Swissprot: P29218

Santa Cruz:

Calculated MW: 30 kDa

Observed MW: Refer to figures

Concentration: 0.72 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IMPA1 Polyclonal Antibody DataSheet