IPO5 Polyclonal Antibody | G-AB-09873

IPO5 Polyclonal Antibody | G-AB-09873 | Gentaur Antibodies

Overview: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: IPO5, IMB3, KPNB3, Pse1, RANBP5, imp5

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 3843

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human IPO5 (NP_002262.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: O00410

Santa Cruz:

Calculated MW: 116 kDa/123 kDa/125 kDa

Observed MW: 124 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IPO5 Polyclonal Antibody DataSheet