IQGAP3 Polyclonal Antibody | G-AB-12172

IQGAP3 Polyclonal Antibody | G-AB-12172 | Gentaur Antibodies

Overview: IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1, 631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience, Signal Transduction

Synonyms: IQGAP3

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 128239

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human IQGAP3 (NP_839943.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q86VI3

Santa Cruz:

Calculated MW: 184 kDa

Observed MW: 185 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IQGAP3 Polyclonal Antibody DataSheet