IRAK1BP1 Polyclonal Antibody | G-AB-00563

IRAK1BP1 Polyclonal Antibody | G-AB-00563 | Gentaur Antibodies

Overview: SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1) , is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

Category Type: Polyclonal Antibody

Research Areas: Immunology, Signal Transduction

Synonyms: ActA binding protein 3, AIP70, Interleukin 1 receptor associated kinase 1 binding protein 1, IRAK1-binding protein 1, Signaling molecule that associates with Pelle-like kinase, SIMPL

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC112253

Clonality: Polyclonal

Immunogen: Recombinant protein of human IRAK1BP1

Clone #:

Conjugation: Unconjugated

Swissprot: Q5VVH5

Santa Cruz: sc-169315/sc-169314

Calculated MW: 29 kDa

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IRAK1BP1 Polyclonal Antibody DataSheet