IREB2 Polyclonal Antibody | G-AB-11057

IREB2 Polyclonal Antibody | G-AB-11057 | Gentaur Antibodies

Overview: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES) , stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD) . Alternative splicing results in multiple transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cardiovascular, Metabolism

Synonyms: IREB2, ACO3, IRP2, IRP2AD

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 3658

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human IREB2 (NP_004127.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P48200

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:20-1:50

Storage: Store at -20°C. Avoid freeze / thaw cycles.

IREB2 Polyclonal Antibody DataSheet