JNK1/2/3 Polyclonal Antibody | G-AB-05908

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$163.00 - $465.00
3 to 5 Working Days
Human, Mouse, Rat, Chicken
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JNK1/2/3 Polyclonal Antibody | G-AB-05908 | Gentaur Antibodies

Overview: c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1α1, JNK1β1, JNK2α1, JNK2β1 and JNK3α1, which represent the p46 isoforms, and JNK1α2, JNK1β2, JNK2α2, JNK2β2 and JNK3β2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Signal Transduction

Synonyms: MAPK8, JNK1, PRKM8, SAPK1, SAPK1C, Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK9, JNK2, PRKM9, SAPK1A, Mi

Reactivity: Human, Mouse, Rat, Chicken

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human JNK1/2/3 around the non-phosphorylation site of Thr183.

Clone #:

Conjugation: Unconjugated

Swissprot: P45983, P45984, P53779

Santa Cruz:

Calculated MW: 48 kDa

Observed MW: 44 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, IF, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

JNK1/2/3 Polyclonal Antibody DataSheet

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