JNK1 Polyclonal Antibody | G-AB-07173

JNK1 Polyclonal Antibody | G-AB-07173 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Signal Transduction

Synonyms: MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5599

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human JNK1 (NP_620635.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P45983

Santa Cruz:

Calculated MW: 35 kDa/44 kDa/48 kDa

Observed MW: 50 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

JNK1 Polyclonal Antibody DataSheet

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