KDM4D Polyclonal Antibody | G-AB-06065

KDM4D Polyclonal Antibody | G-AB-06065 | Gentaur Antibodies

Overview: JMJD2D (Jumonji domain-containing protein 2D) , also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: JHD3D, JHDM3D, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, Kdm4d, KDM4D, Lysine-specific demethylase 4D

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP060509

Clonality: Polyclonal

Immunogen: Synthetic peptide of human KDM4D

Clone #:

Conjugation: Unconjugated

Swissprot: Q6B0I6

Santa Cruz:

Calculated MW: 58 kDa

Observed MW: Refer to figures

Concentration: 0.78 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

KDM4D Polyclonal Antibody DataSheet