KIR3DL1 Polyclonal Antibody | G-AB-06680

KIR3DL1 Polyclonal Antibody | G-AB-06680 | Gentaur Antibodies

Overview: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) , while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: AMB11, CD158 antigen-like family member E, CD158e, CD158e antigen, CD158E1, CD158E1/2, CD158E2, CL11, CL2, HLA-BW4-specific inhibitory NK cell receptor, KI3L1, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains, short cytoplasmic tail, 1, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, Killer cell immunoglobulin-like receptor 3DL1, KIR, KIR antigen 3DL1, KIR G1, Kir3dl1, KIR3DS1, Kirl1, Kirl2, Krl1, MGC119726, MGC119728, MGC126589, MGC126591, MHC class I NK cell receptor, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, Natural killer-associated transcript 3, NK receptor, NK-associated transcript 10, NK-associated transcript 3, NK-associated transcript 3delIg1, NKAT-3, NKAT10, NKAT3, NKB1, NKB1B, p70 killer cell inhibitory receptor, p70 natural killer cell receptor clones CL 2/CL 11, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC028206

Clonality: Polyclonal

Immunogen: Fusion protein of human KIR3DL1

Clone #:

Conjugation: Unconjugated

Swissprot: P43629

Santa Cruz:

Calculated MW: 49 kDa

Observed MW: Refer to figures

Concentration: 1.86 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

KIR3DL1 Polyclonal Antibody DataSheet