KLRK1 Polyclonal Antibody | G-AB-10946

KLRK1 Polyclonal Antibody | G-AB-10946 | Gentaur Antibodies

Overview: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 22914

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human KLRK1 (NP_031386.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P26718

Santa Cruz:

Calculated MW: 25 kDa

Observed MW: 30 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

KLRK1 Polyclonal Antibody DataSheet