(KO Validated) APEX1 Polyclonal Antibody | G-AB-10147

(KO Validated) APEX1 Polyclonal Antibody | G-AB-10147 | Gentaur Antibodies

Overview: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling

Synonyms: APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 328

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human APEX1 (NP_542380.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P27695

Santa Cruz:

Calculated MW: 35 kDa

Observed MW: 39 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) APEX1 Polyclonal Antibody DataSheet