(KO Validated) BCL10 Polyclonal Antibody | G-AB-07473

(KO Validated) BCL10 Polyclonal Antibody | G-AB-07473 | Gentaur Antibodies

Overview: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD) , and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms: BCL10, CARMEN, CIPER, CLAP, IMD37, c-E10, mE10

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 8915

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human BCL10 (NP_003912.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O95999

Santa Cruz:

Calculated MW: 26 kDa

Observed MW: 33 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) BCL10 Polyclonal Antibody DataSheet