(KO Validated) CBX3 Polyclonal Antibody | G-AB-10025

(KO Validated) CBX3 Polyclonal Antibody | G-AB-10025 | Gentaur Antibodies

Overview: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: CBX3, HECH, HP1-GAMMA, HP1Hs-gamma

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 11335

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CBX3 (NP_009207.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13185

Santa Cruz:

Calculated MW: 20 kDa

Observed MW: 23 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) CBX3 Polyclonal Antibody DataSheet