(KO Validated) NCOA2 Polyclonal Antibody | G-AB-07355

(KO Validated) NCOA2 Polyclonal Antibody | G-AB-07355 | Gentaur Antibodies

Overview: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms: NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10499

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NCOA2 (NP_006531.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q15596

Santa Cruz:

Calculated MW: 159 kDa

Observed MW: 200 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) NCOA2 Polyclonal Antibody DataSheet