(KO Validated) ROCK1 Polyclonal Antibody | G-AB-07304

(KO Validated) ROCK1 Polyclonal Antibody | G-AB-07304 | Gentaur Antibodies

Overview: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Signal Transduction

Synonyms: ROCK1, P160ROCK, ROCK-I

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 6093

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ROCK1 (NP_005397.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13464

Santa Cruz:

Calculated MW: 158 kDa

Observed MW: 158 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) ROCK1 Polyclonal Antibody DataSheet