KRT6A Polyclonal Antibody | G-AB-11753

KRT6A Polyclonal Antibody | G-AB-11753 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: KRT6A, CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 3853

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human KRT6A (NP_005545.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P02538

Santa Cruz:

Calculated MW: 60 kDa

Observed MW: 50 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

KRT6A Polyclonal Antibody DataSheet