LEPR Polyclonal Antibody | G-AB-10242

LEPR Polyclonal Antibody | G-AB-10242 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) , and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms: CD295, LEP-R, LEPRD, OB-R, OBR, LEPR

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 3953

Accession #:

Clonality:

Immunogen: A synthetic peptide of human LEPR

Clone #:

Conjugation: Unconjugated

Swissprot: P48357

Santa Cruz:

Calculated MW: 96 kDa/102 kDa/103 kDa/109 kDa/132 kDa

Observed MW: 113 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

LEPR Polyclonal Antibody DataSheet