MAP2K2 Polyclonal Antibody | G-AB-01333

MAP2K2 Polyclonal Antibody | G-AB-01333 | Gentaur Antibodies

Overview: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor Signal Transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome) , a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: Cardiofaciocutaneous syndrome, CFC syndrome, CFC4, Dual specificity mitogen activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, map2k2, MAPK / ERK kinase 2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, Microtubule associated protein kinase kinase 2, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, MKK 2, MKK2, MP2K2, OTTHUMP00000165826, OTTHUMP00000165827, PRKMK 2, PRKMK2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_109587

Clonality: Polyclonal

Immunogen: Synthetic peptide of human MAP2K2

Clone #:

Conjugation: Unconjugated

Swissprot: P36507

Santa Cruz: sc-525/sc-524

Calculated MW: 44 kDa

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:1000-1:5000, IHC 1:100-1:300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MAP2K2 Polyclonal Antibody DataSheet