(KO Validated) MAP2K2 Polyclonal Antibody | G-AB-08805
- 3 to 5 Working Days
- Human, Mouse, Rat
(KO Validated) MAP2K2 Polyclonal Antibody | G-AB-08805 | Gentaur Antibodies
Overview: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor Signal Transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome) , a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Signal Transduction
Synonyms: CFC4, MAPKK2, MEK2, MKK2, PRKMK2, MAP2K2
Reactivity: Human, Mouse, Rat
Gene ID: 5605
Immunogen: A synthetic peptide of human MAP2K2 (NP_109587.1) .
Calculated MW: 44 kDa
Observed MW: 50 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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