Phospho-MAP2K1（S217）/MAP2K2（S221） Polyclonal Antibody | G-AB-12533
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-MAP2K1（S217）/MAP2K2（S221） Polyclonal Antibody | G-AB-12533 | Gentaur Antibodies
Overview: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs) , act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase Signal Transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development./The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor Signal Transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome) , a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Category Type: Phosphorylated antibody
Reactivity: Human, Mouse, Rat
Gene ID: 5604/5605
Immunogen: A phospho specific peptide corresponding to residues surrounding serine 217/221 of human MAP2K1/MAP2K2.
Swissprot: Q02750, P36507
Calculated MW: 40 kDa/43 kDa/44 kDa
Observed MW: 44 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:1000
Storage: Store at -20°C. Avoid freeze / thaw cycles.