MAP2K3 Polyclonal Antibody | G-AB-11825
- 3 to 5 Working Days
- Human, Mouse, Rat
MAP2K3 Polyclonal Antibody | G-AB-11825 | Gentaur Antibodies
Overview: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction
Synonyms: MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
Reactivity: Human, Mouse, Rat
Gene ID: 5606
Immunogen: Recombinant fusion protein of human MAP2K3 (NP_659731.1) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IHC, IF
Dilution: IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.