MAP3K3 Polyclonal Antibody | G-AB-09295

MAP3K3 Polyclonal Antibody | G-AB-09295 | Gentaur Antibodies

Overview: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) -dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Signal Transduction

Synonyms: MAP3K3, MAPKKK3, MEKK3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4215

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human MAP3K3 (NP_976226.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q99759

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MAP3K3 Polyclonal Antibody DataSheet