MDM4 Polyclonal Antibody | G-AB-09704

MDM4 Polyclonal Antibody | G-AB-09704 | Gentaur Antibodies

Overview: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Synonyms: MDM4, HDMX, MDMX, MRP1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 4194

Accession #:

Clonality:

Immunogen: A synthetic peptide of human MDM4

Clone #:

Conjugation: Unconjugated

Swissprot: O15151

Santa Cruz:

Calculated MW: 13 kDa/14 kDa/18 kDa/49 kDa/54 kDa

Observed MW: 47 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MDM4 Polyclonal Antibody DataSheet