MonoMethyl-UHRF1-K385 Polyclonal Antibody | G-AB-09270
- 3 to 5 Working Days
- Human, Mouse, Rat
MonoMethyl-UHRF1-K385 Polyclonal Antibody | G-AB-09270 | Gentaur Antibodies
Overview: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Category Type: Methylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Synonyms: UHRF1, ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95
Reactivity: Human, Mouse, Rat
Gene ID: 29128
Immunogen: A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.