MSR1 Polyclonal Antibody | G-AB-08599
Gentaur Antibodies
- SKU:
- G-AB-08599
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
MSR1 Polyclonal Antibody | G-AB-08599 | Gentaur Antibodies
Overview: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs) . The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology
Synonyms: MSR1, CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 4481
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human MSR1 (NP_619729.1) .
Clone #:
Conjugation: Unconjugated
Swissprot: P21757
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IF
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.